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吃什么“解药”能快速醒酒?解酒药是真的吗?

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11个月前
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本文最后更新于2021年02月01日,已超过355天没有更新,若内容或图片失效,请留言反馈。

世上真的有“喝前2粒酒场不惧”“酒后10分钟化酒为水”的药物吗?解酒药到底靠不靠谱?

解毒过程

一切还要从酒精的解毒过程说起。

酒精进入消化道以后,约10%会在胃被代谢掉,剩余的90%很快进入血液。除少量可以从尿、汗液及呼气排出外,剩下的90%以上的酒精需在肝脏中代谢。

肝脏代谢酒精主要有以下3个步骤:

  1. 在乙醇脱氢酶的作用下,将酒精转化成乙醛;①
  2. 在乙醛脱氢酶的作用下,将乙醛转化为乙酸;②
  3. 通过三羧酸循环的生化反应,将乙酸转化为二氧化碳和水,排泄出体外。③

对我们来说,如果喝得不是太多,上面的第①步可以很快完成,很多人其实是卡在了第②步。因为,不同的人体内,乙醛脱氢酶的含量不同。乙醛脱氢酶相对缺乏的人,不能将乙醛继续完全转化为乙酸,乙醛就会在体内蓄积。这个东西可比酒精毒多了,是一级致癌物,可以导致毛细血管扩张,产生脸红、心悸、恶心等不适。

而我们中国人里,偏偏约40~50%的人都天生缺乏乙醛脱氢酶!

脸红更容易醉酒

所以那些“喝酒脸红”的人,并不是酒量大,相反,他们体内的乙醛脱氢酶可能相对缺乏、更容易醉酒。

乙醛脱氢酶相对富足的人,则可以很快地将乙醛代谢为无毒的乙酸、分解为二氧化碳和水排出体外。这种人才是真的“酒量大”、不容易醉。

但如果摄入的酒精超过了肝脏的代谢能力,即使酒量再大、酒精浓度在体内也会急剧升高,还是会醉!

科学防止醉酒

这样看来,要想防止醉酒,不外乎以下两条途径:

  1. 减少或延缓酒精在人体的吸收
    酒精分子很小、很容易穿过肠壁进入血管、化学性质相对稳定,不太可能“与其他物质结合沉淀”来减少吸收。“延缓吸收”倒是可以做到,比如喝酒前适当吃些主食、让酒精在胃里多待一会儿。这也就是为什么常说“垫一垫肚子不容易醉”。但这样依然治标不治本。
  2. 增加乙醛脱氢酶的量或活性,加快酒精代谢过程
    人体里有多少乙醛脱氢酶,只和基因有关,理论上每个人出生后,体内的酶量就已经固定了。所以“酒量”基本是天生的,不可能通过每天少量喝酒、让乙醛脱氢酶的量发生改变。

有解酒药吗?

那如果发明一种药,专门补充肝脏乙醛脱氢酶,是不是就能解酒了呢?

太天真!酶的本质是蛋白质,进入胃酸后就会失去活性、分解成氨基酸。口服的酶根本进不到肝脏里。
但有人说的“每天喝点小酒”,或许可以让酒量得到部分提高。因为长期饮酒会使肝脏的另外一条“解酒”途径——微粒体乙醇氧化系统的活性得到增强,在这个系统中起关键作用的是细胞色素P-450(CYP)2E1。这个酶,也是我们常说的“肝脏药物代谢酶(肝药酶)”,可以将乙醇代谢为乙醛,类似于前面所说的乙醇脱氢酶。但是,肝药酶仍然无法将乙醛传化为乙酸,所以有毒的乙醛还会继续在肝脏堆积,只能等乙醛脱氢酶前来清理。就像班里打扫卫生,你只是帮忙劳动委员“扫了扫地”,却不去倒垃圾。而且,代谢酒精毕竟不是肝药酶的“正职工作”,只是偶尔客串一下,解酒能力非常有限。所以,长期喝酒能“练”出来的酒量也非常有限。另外,肝药酶和它的代谢产物增加会带来很多危害,久而久之,反而会给肝脏造成严重损伤。

既然乙醛脱氢酶的量是天生决定的,那能不能提高它的活性来解酒呢?

还真有这么一种药,可以相对提高乙醛脱氢酶的活性。研究发现,美他多辛是乙醛脱氢酶激活剂,可拮抗急、慢性酒精中毒引起的乙醇脱氢酶活性下降,加速乙醇及其代谢产物乙醛和酮体经尿液排泄。在健康志愿者中,美他多辛可以让乙醇代谢的半衰期从7小时15分钟缩短至5小时50分钟。

但别高兴得太早,这药不能随便用!

美他多辛属于处方药,只用于酒精性肝病的治疗,需要在医生的指导下凭处方购买使用。需要特别注意的是,美他多辛可能会引起周围神经疾病!而且,支气管哮喘者及儿童不能使用。

那市面上那么多解酒药,就没有有用的?

市面上宣称的所谓“解酒药”,成分大多是一些植物提取物或药食两用的原料,如姜黄、牡蛎提取物、栀子、枸杞、丹参、茯苓、大麦嫩苗、甲壳素等,也有一些含有蛋白质、维生素、某些矿物质等营养成分,以进口膳食补充剂为主,国产的如果是正规保健食品,会有“蓝帽子”的标志。但这些都属于食品,并不是真正的“药”。

还有一类确实是某些化学成分如纳络酮、利尿剂等,是印有国药准字的药品。纳洛酮是阿片类药物 (包含海洛因等毒品) 过量的解毒剂,也能解除酒精的中枢抑制、缩短昏迷时间。说白了,它只能让你变清醒,但无法加速乙醛的“解毒”过程。而且这个药是处方药,不能随便用,还可能导致躁狂。在医院急救时一般是直接静脉输液,而不是舌下含服。

总之,无论是上面哪种成分的“解酒药”,都没有明确研究证明能提高乙醛脱氢酶的量或活性,所以起不到真正解酒的作用!

“酒量大增、千杯不醉”的广告只是心理安慰,乱吃解酒药反而可能增加肝脏负担。严肃地提醒各位:防止醉酒的唯一途径,还是少喝或不喝酒。

解酒食物有效吗?

很遗憾,除了解酒药,民间流传的“解酒食物”对醉酒也没有帮助。

蜂蜜中的果糖可以轻微提高乙醇脱氢酶的效率,但对更毒的乙醛无能为力。浓茶咖啡利尿,可能加重脱水症状,反而增加了体内酒精浓度。

醉酒的人如果还能行动,不如适当喝一些温水、吃点水果(不是因为果糖,主要是补充钠钾镁离子、缓解脱水症状)。如果呕吐完症状好转,可以侧卧休息,但要有人陪护。

如果你的朋友或亲人已经大醉不醒了(昏迷期),记得一定要让TA侧卧,防止呕吐物误吸入气道引起窒息!然后尽快拨打120送医院吧。

最后,课代表给大家划重点来了:

  • 人体“解酒”主要靠乙醛脱氢酶,但酶的量是天生的,吃药无法补充。只有美他多辛可提高酶的活性,但这是处方药,不能随便用。
  • 市面上的“解酒药”多是植物提取物或维生素,或是利尿剂、促醒剂等,但都无法提高乙醛脱氢酶的量或活性,并不能真正解酒。
  • 如果已经醉酒,蜂蜜、浓茶和咖啡都对解酒没有帮助,还不如喝些温水补充水分,自然醒酒。

酒量能练吗?

“喝酒脸红”和“喝酒脸白”谁更能喝?酒量能练吗?

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2021 年 02 月 01 日 02 : 52 PM

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  1. ZMR秀才
    2022-01-19

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}!}

  2. ZMR秀才
    2022-01-19
  3. ZMR秀才
    2022-01-19

    666

  4. Joe秀才
    2022-01-17
  5. ErenYeagerGuo秀才
    2022-01-15